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Background
Contents:
  1. Structural and Biological Overview of Boron-containing Amino Acids in the Medicinal Chemistry Field
  2. A-Z Index of Tox Profiles
  3. Functionalized 3-pyrrolyl boron-dipyrromethenes - RSC Advances (RSC Publishing)
  4. Boron arsenide (T3D1290)

General Function: Oxygen transporter activity Specific Function: Involved in oxygen transport from the lung to the various peripheral tissues. LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure. Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.

Targets PGAM5 for ubiquitination and degradation by the proteasome. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 Th1 cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. General Function: Pyruvate dehydrogenase activity Specific Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO 2 , and thereby links the glycolytic pathway to the tricarboxylic cycle.

General Function: Pyruvate dehydrogenase acetyl-transferring activity Specific Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO 2 , and thereby links the glycolytic pathway to the tricarboxylic cycle. General Function: Transferase activity, transferring acyl groups Specific Function: Required for anchoring dihydrolipoamide dehydrogenase E3 to the dihydrolipoamide transacetylase E2 core of the pyruvate dehydrogenase complexes of eukaryotes.

This specific binding is essential for a functional PDH complex. General Function: Thioredoxin-disulfide reductase activity Specific Function: Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions.

Structural and Biological Overview of Boron-containing Amino Acids in the Medicinal Chemistry Field

Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid. General Function: Thioredoxin-disulfide reductase activity Specific Function: Maintains thioredoxin in a reduced state.

Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.

A-Z Index of Tox Profiles

General Function: Thioredoxin-disulfide reductase activity Specific Function: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components By similarity. General Function: Structural constituent of cytoskeleton Specific Function: Tubulin is the major constituent of microtubules.

It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain By similarity. General Function: Tubulin is the major constituent of microtubules.

Functionalized 3-pyrrolyl boron-dipyrromethenes - RSC Advances (RSC Publishing)

It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. General Function: Ubiquitin protein ligase binding Specific Function: Tubulin is the major constituent of microtubules. General Function: Structural molecule activity Specific Function: Tubulin is the major constituent of microtubules. TUBB2B is implicated in neuronal migration.

TUBB3 plays a critical role in proper axon guidance and mantainance. General Function: Unfolded protein binding Specific Function: Tubulin is the major constituent of microtubules.


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Boron arsenide is a chemical compound of arsenic and boron. Synonym B-As. This compound belongs to the class of inorganic compounds known as homogeneous metalloid compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a metalloid atom. Inorganic compounds. Homogeneous metal compounds. Homogeneous metalloid compounds. If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center.

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Some synthetic BCCs are commonplace today, especially boric, boronic and borinic acids used to produce textiles, detergents, glass, semi-conductors, and materials for protecting against radiation. Moreover, boron fibers are employed for configurational mechanics, amorphous boron for pyrotechnics, and boron atoms for the detection of neutrons in nuclear reactors.